The Ultimate 21-Day South American Backpacking Route

Backpacking through South America is a dream for many travelers, offering vibrant cultures, breathtaking landscapes, and endless adventure. This ultimate 21-day itinerary takes you through some of the continent's most iconic destinations, allowing you to immerse yourself in its rich history and natural beauty. Prepare for a journey that covers diverse environments, including lush rainforests, towering mountains, and vibrant cities.

Day 1-3: Buenos Aires, Argentina

Your adventure begins in Buenos Aires, the capital of Argentina. Spend your days wandering through the colorful streets of La Boca, visiting the historic San Telmo market, and indulging in authentic Argentine cuisine. Don’t miss a tango show to experience the country's famous dance culture. A guided walking tour can give you insights into the city's history and help you find hidden gems. After three days of exploring, you'll be ready to dive deeper into South America.

Day 4-7: Mendoza, Argentina

Next, head to Mendoza, the heart of Argentina's wine country. Take a bus or a short flight for a change in scenery. Spend your first day relaxing and strolling through the beautiful plazas. On Day 5, embark on a wine-tasting tour, visiting several vineyards and sampling some of the finest Malbecs. A hot air balloon ride over the vineyards is an unforgettable experience that offers stunning views. On Day 7, prepare for an adventurous excursion to the Andes Mountains, where you can hike, bike, or enjoy an exhilarating day of white-water rafting.

Day 8-10: Santiago, Chile

Your next destination is Santiago, a bustling city surrounded by mountains. Simply travel across the Andes to reach Chile's capital. Spend a couple of days here soaking in the city's rich culture and history. Visit the historic center, Plaza de Armas, and the stunning Cerro San Cristóbal for panoramic views. Take a day trip to Valparaiso, a UNESCO World Heritage Site known for its colorful houses and vibrant street art. The final day in Santiago can include a visit to the Mercado Central for some delicious local seafood and an exploration of the city's artistic districts.

Day 11-12: Atacama Desert, Chile

From Santiago, fly to Calama and then transfer to San Pedro de Atacama, the gateway to the Atacama Desert. Over two days, explore the otherworldly landscapes, including Valle de la Luna, geysers, and the stunning salt flats. Don't miss stargazing at one of the clearest skies on the planet; the experience is something truly special. Engage in a guided tour to become familiar with the fascinating geography, wildlife, and the history of indigenous peoples in the region.

Day 13-15: Uyuni, Bolivia

Cross the border into Bolivia and head to the town of Uyuni, famous for its salt flats. Take a multi-day jeep tour to explore the surreal Salar de Uyuni and surrounding natural wonders like colorful lagoons, hot springs, and volcanic formations. Sleeping in a salt hotel is a unique experience that adds to the adventure. Be prepared for some incredible photo opportunities and the chance to encounter unique wildlife, such as flamingos.

Day 16-18: La Paz, Bolivia

After your rugged adventure in Uyuni, make your way to La Paz, the highest capital city in the world. Take a moment to acclimatize and explore the city’s unique topography. Visit the Witches’ Market and explore the stunning architecture in the Valle de la Luna. Adventurous travelers may enjoy biking down the infamous Death Road, a thrilling experience for those looking for adrenaline. Spend a day visiting nearby ruins like Tiwanaku, to understand more about the ancient civilizations that inhabited the region.

Day 19-21: Cusco and Machu Picchu, Peru

Your backpacking route ends in Cusco, the historic capital of the Inca Empire. Spend a day exploring the city before heading out on a trek to Machu Picchu. Options range from the classic Inca Trail to the less crowded Salkantay or Lares treks. The journey will lead you through breathtaking scenery, with the opportunity to interact with local communities along the way. Finally, embrace the awe-inspiring view of Machu Picchu. Take your time exploring the ruins and learning about Inca history, then return to Cusco to reflect on your incredible journey.

This 21-day itinerary offers a perfect blend of culture, adventure, and breathtaking scenery, making it an unforgettable South American backpacking experience. Each stop provides an opportunity to connect with the local culture, taste regional foods, and meet fellow travelers. As you navigate through diverse landscapes and immerse yourself in every destination, embrace the spirit of adventure that backpacking through South America uniquely provides.